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Transposable Element Exaptation into Regulatory Regions Is Rare, Influenced by Evolutionary Age, and Subject to Pleiotropic Constraints

Transposable element (TE)-derived sequences make up approximately half of most mammalian genomes, and many TEs have been co-opted into gene regulatory elements. However, we lack a comprehensive tissue- and genome-wide understanding of how and when TEs gain regulatory activity in their hosts. We eval...

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Détails bibliographiques
Publié dans:Mol Biol Evol
Auteurs principaux: Simonti, Corinne N., Pavličev, Mihaela, Capra, John A.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850124/
https://ncbi.nlm.nih.gov/pubmed/28961735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msx219
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