Mangiferin Improves Hepatic Lipid Metabolism Mainly Through Its Metabolite-Norathyriol by Modulating SIRT-1/AMPK/SREBP-1c Signaling

Objective: Mangiferin (MGF) is a natural xanthone, with regulation effect on lipid metabolism. However, the molecular mechanism remains unclear. We purposed after oral administration, MGF is converted to its active metabolite(s), which contributes to the effects on lipid metabolism. Methods: KK-A(y)...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Li, Jian, Liu, Mengyang, Yu, Haiyang, Wang, Wei, Han, Lifeng, Chen, Qian, Ruan, Jingya, Wen, Shaoshi, Zhang, Yi, Wang, Tao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850072/
https://ncbi.nlm.nih.gov/pubmed/29563875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00201
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