Mangiferin Improves Hepatic Lipid Metabolism Mainly Through Its Metabolite-Norathyriol by Modulating SIRT-1/AMPK/SREBP-1c Signaling

Objective: Mangiferin (MGF) is a natural xanthone, with regulation effect on lipid metabolism. However, the molecular mechanism remains unclear. We purposed after oral administration, MGF is converted to its active metabolite(s), which contributes to the effects on lipid metabolism. Methods: KK-A(y)...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Li, Jian, Liu, Mengyang, Yu, Haiyang, Wang, Wei, Han, Lifeng, Chen, Qian, Ruan, Jingya, Wen, Shaoshi, Zhang, Yi, Wang, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850072/
https://ncbi.nlm.nih.gov/pubmed/29563875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00201
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