Co-delivery of Aurora-A inhibitor XY-4 and Bcl-xl siRNA enhances antitumor efficacy for melanoma therapy

BACKGROUND: The newly synthesized Aurora-A kinase inhibitor XY-4 is a potential anti-cancer agent, but its hydrophobicity and limited efficiency restrict further application. Nanotechnology based combined therapy provides an optimized strategy for solving these issues. METHODS: In this study, the ne...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Duan, Xingmei, Mu, Minjie, Yan, Junfeng, Bai, Lan, Zhong, Lei, Zhu, Yuxuan, Pan, Haixia, Zhang, Mei, Shi, Jianyou
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849942/
https://ncbi.nlm.nih.gov/pubmed/29563798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S147759
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