Structure-based design of chimeric antigens for multivalent protein vaccines

There is an urgent need to develop vaccines against pathogenic bacteria. However, this is often hindered by antigenic diversity and difficulties encountered manufacturing membrane proteins. Here we show how to use structure-based design to develop chimeric antigens (ChAs) for subunit vaccines. ChAs...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Hollingshead, S., Jongerius, I., Exley, R. M., Johnson, S., Lea, S. M., Tang, C. M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849709/
https://ncbi.nlm.nih.gov/pubmed/29535307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03146-7
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