Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic-ischemic insult in neonatal mice: effects of injury, microglial activation and hypothermia

Perinatal hypoxic-ischemic encephalopathy (HIE) can result in neurodevelopmental disability, including cerebral palsy. The only treatment, hypothermia, provides incomplete neuroprotection. Hydroxyl polyamidoamine (PAMAM) dendrimers are being explored for targeted delivery of therapy for HIE. Underst...

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Publicado en:Nanomedicine
Main Authors: Nemeth, Christina L., Drummond, Gabrielle T., Mishra, Manoj K., Zhang, Fan, Carr, Patrice, Garcia, Maxine S., Doman, Sydney, Fatemi, Ali, Johnston, Michael V., Kannan, Rangaramanujam M., Kannan, Sujatha, Wilson, Mary Ann
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849407/
https://ncbi.nlm.nih.gov/pubmed/28669854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2017.06.014
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