Alkynyl-Containing Phenylthiazoles: Systemically Active Antibacterial Agents Effective Against Methicillin-resistant Staphylococcus aureus (MRSA)

The promising activity of phenylthiazoles against multidrug-resistant bacterial pathogens, in particular MRSA, has been hampered by their limited systemic applicability, due to their rapid metabolism by hepatic microsomal enzymes, resulting in short half-lives. Here, we investigated a series of phen...

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Bibliographic Details
Published in:Eur J Med Chem
Main Authors: Elsebaei, Mohamed M., Mohammad, Haroon, Abouf, Mohamed, Abutaleb, Nader S., Hegazy, Youssef A., Ghiaty, Adel, Chen, Lu, Zhang, Jianan, Malwal, Satish R., Oldfield, Eric, Seleem, Mohamed N., Mayhoub, Abdelrahman S.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849061/
https://ncbi.nlm.nih.gov/pubmed/29459278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.02.031
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