Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma

ErbB3 has been widely implicated in treatment resistance, but its role as a primary treatment target is less clear. Canonically ErbB3 requires EGFR or ErbB2 for activation, whereas these two established treatment targets are thought to signal independently of ErbB3. In this study, we show that ErbB3...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Death Dis
Hlavní autoři: Redlich, Nathan, Robinson, Anthony M., Nickel, Kwangok P., Stein, Andrew P., Wheeler, Deric L., Adkins, Douglas R., Uppaluri, Ravindra, Kimple, Randall J., Van Tine, Brian A., Michel, Loren S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849045/
https://ncbi.nlm.nih.gov/pubmed/29305574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0029-0
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky