The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality worldwide and is associated with poor prognosis, especially in patients not amenable for curative treatments. The multi-kinase inhibitor sorafenib represents the first-line treatment option for advanced HCC; never...

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Vydáno v:Cell Death Dis
Hlavní autoři: Pollutri, Daniela, Patrizi, Clarissa, Marinelli, Sara, Giovannini, Catia, Trombetta, Elena, Giannone, Ferdinando A., Baldassarre, Maurizio, Quarta, Santina, Vandewynckel, Y. P., Vandierendonck, A., Van Vlierberghe, H., Porretti, Laura, Negrini, Massimo, Bolondi, Luigi, Gramantieri, Laura, Fornari, Francesca
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849044/
https://ncbi.nlm.nih.gov/pubmed/29305580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0076-6
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