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Whole-exome sequencing of sickle cell disease patients with hyperhemolysis syndrome suggests a role for rare variation in disease predisposition

BACKGROUND: Hyperhemolysis syndrome (HHS) is an uncommon, but life-threatening, transfusion-related complication of red blood cell transfusion. HHS has predominantly been described in patients with sickle cell disease (SCD) and is difficult to diagnose and treat. The pathogenesis of HHS, including i...

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Detalhes bibliográficos
Publicado no:Transfusion
Main Authors: Mwesigwa, Savannah, Moulds, Joann M., Chen, Alice, Flanagan, Jonathan, Sheehan, Vivien A., George, Alex, Hanchard, Neil A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847445/
https://ncbi.nlm.nih.gov/pubmed/29210071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.14431
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