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Pediatric Pharmacogenomics: A systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children
The dose-exposure-response relationship for drugs may differ in pediatric patients compared to adults due to developmental changes in processes involved in drug disposition (absorption, distribution, metabolism and excretion) and drug response. This relative knowledge deficit has complicated drug ef...
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| 發表在: | Pediatr Clin North Am |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5847265/ https://ncbi.nlm.nih.gov/pubmed/23036242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pcl.2012.07.008 |
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