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Pediatric Pharmacogenomics: A systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children

The dose-exposure-response relationship for drugs may differ in pediatric patients compared to adults due to developmental changes in processes involved in drug disposition (absorption, distribution, metabolism and excretion) and drug response. This relative knowledge deficit has complicated drug ef...

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書目詳細資料
發表在:Pediatr Clin North Am
Main Authors: Wagner, Jonathan, Leeder, J. Steven
格式: Artigo
語言:Inglês
出版: 2012
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847265/
https://ncbi.nlm.nih.gov/pubmed/23036242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pcl.2012.07.008
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