A facile doxorubicin-dichloroacetate conjugate nanomedicine with high drug loading for safe drug delivery

BACKGROUND: Doxorubicin (DOX) is an effective chemotherapeutic agent but severe side effects limit its clinical application. Nanoformulations can reduce the toxicity while still have various limitations, such as complexity, low drug loading capability and excipient related concerns. METHODS: An amph...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Yang, Conglian, Wu, Tingting, Qin, Yuting, Qi, Yan, Sun, Yu, Kong, Miao, Jiang, Xue, Qin, Xianya, Shen, Yaqi, Zhang, Zhiping
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846746/
https://ncbi.nlm.nih.gov/pubmed/29563787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S154361
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