Computational antimicrobial peptide design and evaluation against multidrug-resistant clinical isolates of bacteria

There is a pressing need for new therapeutics to combat multidrug- and carbapenem-resistant bacterial pathogens. This challenge prompted us to use a long short-term memory (LSTM) language model to understand the underlying grammar, i.e. the arrangement and frequencies of amino acid residues, in know...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Nagarajan, Deepesh, Nagarajan, Tushar, Roy, Natasha, Kulkarni, Omkar, Ravichandran, Sathyabaarathi, Mishra, Madhulika, Chakravortty, Dipshikha, Chandra, Nagasuma
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846155/
https://ncbi.nlm.nih.gov/pubmed/29259134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.805499
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