Cardiac-Specific Deletion of Pyruvate Dehydrogenase Impairs Glucose Oxidation Rates and Induces Diastolic Dysfunction

Obesity and type 2 diabetes (T2D) increase the risk for cardiomyopathy, which is the presence of ventricular dysfunction in the absence of underlying coronary artery disease and/or hypertension. As myocardial energy metabolism is altered during obesity/T2D (increased fatty acid oxidation and decreas...

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Publicado en:Front Cardiovasc Med
Autores principales: Gopal, Keshav, Almutairi, Malak, Al Batran, Rami, Eaton, Farah, Gandhi, Manoj, Ussher, John Reyes
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Cardiovascular Medicine
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845646/
https://ncbi.nlm.nih.gov/pubmed/29560354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2018.00017
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