Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs

Background: Chronic hypoxia and oxidative stress during gestation lead to pulmonary hypertension of the neonate (PHN), a condition characterized by abnormal pulmonary arterial reactivity and remodeling. Melatonin has strong antioxidant properties and improves pulmonary vascular function. Here, we ai...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Astorga, Cristian R., González-Candia, Alejandro, Candia, Alejandro A., Figueroa, Esteban G., Cañas, Daniel, Ebensperger, Germán, Reyes, Roberto V., Llanos, Aníbal J., Herrera, Emilio A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845624/
https://ncbi.nlm.nih.gov/pubmed/29559926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00185
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