Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways

The small-molecule naphtha [2,3-f]quinoxaline-7,12-dione (NSC745887) can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. The aim of this study was to elucidate cellular responses of NSC745887 in human glioblastoma multiforme (GBM, U118MG and U87MG cel...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Fann, Li-Yun, Chen, Ying, Chu, Da-Chen, Weng, Shao-Ju, Chu, Heng-Cheng, Wu, Alexander T.H., Lee, Jiann-Fong, Ali, Ahmed Atef Ahmed, Chen, Tsung-Chih, Huang, Hsu-Shan, Ma, Kuo-Hsing
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844718/
https://ncbi.nlm.nih.gov/pubmed/29552282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23714
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