Niemann-Pick type C2 protein supplementation in experimental non-alcoholic fatty liver disease

BACKGROUND AND AIMS: Hepatic cholesterol deposition drives inflammation and fibrosis in non-alcoholic steatohepatitis (NASH). The Niemann-Pick type C2 (NPC2) protein plays an important role in regulating intracellular cholesterol trafficking and homeostasis. We hypothesized that intravenous NPC2 sup...

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Udgivet i:PLoS One
Main Authors: Christensen, Claus Uhrenholt, Glavind, Emilie, Thomsen, Karen Louise, Kim, Yong Ook, Heebøll, Sara, Schuppan, Detlef, Hamilton-Dutoit, Stephen, Würtz Heegaard, Christian, Grønbæk, Henning
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844539/
https://ncbi.nlm.nih.gov/pubmed/29522534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192728
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