Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia

Genome studies of chronic lymphocytic leukemia (CLL) have revealed the remarkable subclonal heterogeneity of the tumors, but the clinical implications of this phenomenon are not well known. We assessed the mutational status of 28 CLL driver genes by deep-targeted next-generation sequencing and copy...

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Publicat a:Leukemia
Autors principals: Nadeu, F, Clot, G, Delgado, J, Martín-García, D, Baumann, T, Salaverria, I, Beà, S, Pinyol, M, Jares, P, Navarro, A, Suárez-Cisneros, H, Aymerich, M, Rozman, M, Villamor, N, Colomer, D, González, M, Alcoceba, M, Terol, M J, Navarro, B, Colado, E, Payer, ÁR, Puente, X S, López-Otín, C, López-Guillermo, A, Enjuanes, A, Campo, E
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2018
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843898/
https://ncbi.nlm.nih.gov/pubmed/28924241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.291
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