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Prophylactic benefits of systemically delivered simvastatin treatment in a house dust mite challenged murine model of allergic asthma

BACKGROUND AND PURPOSE: Systemically delivered statins can blunt airway inflammation in ovalbumin‐challenged mice. However, in asthma clinical trials the beneficial effects of introducing oral statins are not compelling. We have invetigated this discrepancy using a clinically relevant murine model o...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Jha, Aruni, Ryu, Min H, OO, Ojo, Bews, Hilary J, Carlson, Jules C, Schwartz, Jacquie, Basu, Sujata, Wong, Charles S, Halayko, Andrew J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843706/
https://ncbi.nlm.nih.gov/pubmed/29318574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14140
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