Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery

Due to toxicity and compliance issues and the emergence of resistance to current medications new drugs for the treatment of Human African Trypanosomiasis are needed. A potential approach to developing novel anti-trypanosomal drugs is by inhibition of the 6-oxopurine salvage pathways which synthesise...

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Bibliografski detalji
Izdano u:PLoS Negl Trop Dis
Glavni autori: Doleželová, Eva, Terán, David, Gahura, Ondřej, Kotrbová, Zuzana, Procházková, Michaela, Keough, Dianne, Špaček, Petr, Hocková, Dana, Guddat, Luke, Zíková, Alena
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843355/
https://ncbi.nlm.nih.gov/pubmed/29481567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006301
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