KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

Histone modifications, such as the frequently occurring lysine succinylation(1,2), are central to the regulation of chromatin-based processes. However, the mechanism and functional consequences of histone succinylation are unknown. Here we show that the α-ketoglutarate dehydrogenase (α-KGDH) complex...

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Publicat a:Nature
Autors principals: Wang, Yugang, Guo, Yusong R., Liu, Ke, Yin, Zheng, Liu, Rui, Xia, Yan, Tan, Lin, Yang, Peiying, Lee, Jong-Ho, Li, Xin-jian, Hawke, David, Zheng, Yanhua, Qian, Xu, Lyu, Jianxin, He, Jie, Xing, Dongming, Tao, Yizhi Jane, Lu, Zhimin
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841452/
https://ncbi.nlm.nih.gov/pubmed/29211711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25003
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