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PTEN knockdown with the Y444F mutant AAV2 vector promotes axonal regeneration in the adult optic nerve

The lack of axonal regeneration is the major cause of vision loss after optic nerve injury in adult mammals. Activating the PI3K/AKT/mTOR signaling pathway has been shown to enhance the intrinsic growth capacity of neurons and to facilitate axonal regeneration in the central nervous system after inj...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Neural Regen Res
Hauptverfasser: Huang, Zheng-ru, Chen, Hai-ying, Hu, Zi-zhong, Xie, Ping, Liu, Qing-huai
Format: Artigo
Sprache:Inglês
Veröffentlicht: Medknow Publications & Media Pvt Ltd 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840979/
https://ncbi.nlm.nih.gov/pubmed/29451218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1673-5374.224381
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