Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells

In cancer cells, cancer/testis (CT) antigens become epigenetically derepressed through DNA demethylation and constitute attractive targets for cancer immunotherapy. Here we report that activated CD4(+) T helper cells treated with a DNA-demethylating agent express a broad repertoire of endogenous CT...

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Publié dans:Nat Commun
Auteurs principaux: Kirkin, Alexei F., Dzhandzhugazyan, Karine N., Guldberg, Per, Fang, Johnny Jon, Andersen, Rikke S., Dahl, Christina, Mortensen, Jann, Lundby, Tim, Wagner, Aase, Law, Ian, Broholm, Helle, Madsen, Line, Lundell-Ek, Christer, Gjerstorff, Morten F., Ditzel, Henrik J., Jensen, Martin R., Fischer, Walter
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840134/
https://ncbi.nlm.nih.gov/pubmed/29511178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03217-9
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