Congenital Zika Virus Infection as a Silent Pathology With Loss of Neurogenic Output in the Fetal Brain

Zika virus (ZIKV) is a flavivirus with teratogenic effects on the fetal brain, but the spectrum of brain injury is unknown, particularly when ultrasound imaging is normal. In a pregnant pigtail macaque (Macaca nemestrina) model, we demonstrate that ZIKV injury to the fetal brain was significant even...

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Publicat a:Nat Med
Autors principals: Adams Waldorf, Kristina M., Nelson, Branden R., Stencel-Baerenwald, Jennifer E., Studholme, Colin, Kapur, Raj P., Armistead, Blair, Walker, Christie L., Merillat, Sean, Vornhagen, Jay, Tisoncik-Go, Jennifer, Baldessari, Audrey, Coleman, Michelle, Dighe, Manjiri K., Shaw, Dennis W.W., Roby, Justin A., Santana-Ufret, Veronica, Boldenow, Erica, Li, Junwei, Gao, Xiaohu, Davis, Michael A., Swanstrom, Jesica A., Jensen, Kara, Widman, Douglas G., Baric, Ralph S., Medwid, Joseph T., Hanley, Kathryn A., Ogle, Jason, Gough, G. Michael, Lee, Wonsok, English, Chris, Durning, W. McIntyre, Thiel, Jeff, Gatenby, Chris, Dewey, Elyse C., Fairgrieve, Marian R., Hodge, Rebecca D., Grant, Richard F., Kuller, LaRene, Dobyns, William B., Hevner, Robert F., Gale, Michael, Rajagopal, Lakshmi
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839998/
https://ncbi.nlm.nih.gov/pubmed/29400709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4485
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