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Coarse-grained molecular dynamics simulations reveal lipid access pathways in P-glycoprotein
P-glycoprotein (P-gp) exports a broad range of dissimilar compounds, including drugs, lipids, and lipid-like molecules. Because of its substrate promiscuity, P-gp is a key player in the development of cancer multidrug resistance. Although P-gp is one of the most studied ABC transporters, the mechani...
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| Опубликовано в: : | J Gen Physiol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Rockefeller University Press
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5839720/ https://ncbi.nlm.nih.gov/pubmed/29437858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711907 |
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