Intramolecular Hydrogen Bond Activation: Thiourea-Organocatalyzed Enantioselective 1,3-Dipolar Cycloaddition of Salicylaldehyde-Derived Azomethine Ylides with Nitroalkenes

[Image: see text] An organocatalytic strategy for the synthesis of tetrasubstituted pyrrolidines with monoactivated azomethine ylides in high enantiomeric excess and excellent exo/endo selectivity is presented. The key to success is the intramolecular activation via hydrogen bonding through an o-hyd...

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Publicado en:ACS Catal
Main Authors: Esteban, Francisco, Cieślik, Wioleta, Arpa, Enrique M., Guerrero-Corella, Andrea, Díaz-Tendero, Sergio, Perles, Josefina, Fernández-Salas, José A., Fraile, Alberto, Alemán, José
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2018
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839603/
https://ncbi.nlm.nih.gov/pubmed/29527400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.7b03553
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