Ruxolitinib significantly enhances in vitro apoptosis in Hodgkin lymphoma and primary mediastinal B-cell lymphoma and survival in a lymphoma xenograft murine model

Hodgkin lymphoma (HL) and primary mediastinal B-cell lymphoma (PMBL) share similar molecular features by gene expression profiling. Frequent gains of chromosome 9p exhibit higher Janus Kinase 2 (JAK2) transcript levels with increased JAK2 activity, suggesting aberrant activity of JAK2 and STAT pathw...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Lee, Sanghoon, Shah, Tishi, Yin, Changhong, Hochberg, Jessica, Ayello, Janet, Morris, Erin, van de Ven, Carmella, Cairo, Mitchell S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839401/
https://ncbi.nlm.nih.gov/pubmed/29515770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24267
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