A phase-1/2 study of adenovirus-p53 transduced dendritic cell vaccine in combination with indoximod in metastatic solid tumors and invasive breast cancer

BACKGROUND: Indoleamine 2, 3-dioxygenase is an enzyme that causes immunosuppression in tumors. Indoximod inhibits the indoleamine 2, 3-dioxygenase pathway and enhances immunologic responses to dendritic cell (DC) vaccines preclinically. Adenovirus p53 (Ad.p53) is used to generate DC vaccines against...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Soliman, Hatem, Khambati, Fatema, Han, Hyo S., Ismail-Khan, Roohi, Bui, Marilyn M., Sullivan, Daniel M., Antonia, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Clinical Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839376/
https://ncbi.nlm.nih.gov/pubmed/29515795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24118
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