Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca(2+)](i) in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity

AIMS: Protein kinase C (PKC) isozymes contribute to the development of heart failure through dysregulation of Ca(2+) handling properties and disruption of contractile function in cardiomyocytes. However, the mechanisms by which PKC activation leads to Ca(2+) dysfunction are incompletely understood....

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Vydáno v:J Mol Cell Cardiol
Hlavní autoři: Guo, Ang, Chen, Rong, Wang, Yihui, Huang, Chun-Kai, Chen, Biyi, Kutschke, William, Hong, Jiang, Song, Long-Sheng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839099/
https://ncbi.nlm.nih.gov/pubmed/29307535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.01.003
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