Ketamine-Induced Prefrontal Serotonin Release Is Mediated by Cholinergic Neurons in the Pedunculopontine Tegmental Nucleus

BACKGROUND: Ketamine rapidly elicits antidepressive effects in humans and mice in which serotonergic activity is involved. Although α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) in the dorsal raphe nucleus plays a key role in the ketamine-induced prefrontal serotonin release, the source of chol...

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Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Main Authors: Kinoshita, Haruko, Nishitani, Naoya, Nagai, Yuma, Andoh, Chihiro, Asaoka, Nozomi, Kawai, Hiroyuki, Shibui, Norihiro, Nagayasu, Kazuki, Shirakawa, Hisashi, Nakagawa, Takayuki, Kaneko, Shuji
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838842/
https://ncbi.nlm.nih.gov/pubmed/29370396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyy007
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