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Development of Antibody‐Directed Therapies: Quo Vadis?
Less is more: The efficacy of antibody–drug conjugates (ADCs) for cancer therapy is traditionally associated with cleavable linkers for payload release. Evidence now suggests that simpler constructs without cleavable moieties can afford more stable and effective ADCs.[Image: see text]
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Angew Chem Int Ed Engl |
|---|---|
| Prif Awduron: | , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
John Wiley and Sons Inc.
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5838556/ https://ncbi.nlm.nih.gov/pubmed/29341367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201712185 |
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