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Development of Antibody‐Directed Therapies: Quo Vadis?

Less is more: The efficacy of antibody–drug conjugates (ADCs) for cancer therapy is traditionally associated with cleavable linkers for payload release. Evidence now suggests that simpler constructs without cleavable moieties can afford more stable and effective ADCs.[Image: see text]

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Rodrigues, Tiago, Bernardes, Gonçalo J. L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838556/
https://ncbi.nlm.nih.gov/pubmed/29341367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201712185
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