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Early‐Stage Incorporation Strategy for Regioselective Labeling of Peptides using the 2‐Cyanobenzothiazole/1,2‐Aminothiol Bioorthogonal Click Reaction

Herein, we describe a synthetic strategy for the regioselective labeling of peptides by using a bioorthogonal click reaction between 2‐cyanobenzothiazole (CBT) and a 1,2‐aminothiol moiety. This methodology allows for the facile and site‐specific modification of peptides with various imaging agents,...

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Bibliografiske detaljer
Udgivet i:ChemistryOpen
Main Authors: Chen, Kuo‐Ting, Ieritano, Christian, Seimbille, Yann
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838389/
https://ncbi.nlm.nih.gov/pubmed/29531889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201700191
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