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Lack of metabolism in (R)-ketamine’s antidepressant actions in a chronic social defeat stress model
Since the metabolism of (R,S)-ketamine to (2R,6R)-hydroxynorketamine (HNK) is reported to be essential for ketamine’s antidepressant effects, there is an increasing debate about antidepressant effects of (2R,6R)-HNK. Using pharmacokinetic and behavioral techniques, we investigated whether intracereb...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5838158/ https://ncbi.nlm.nih.gov/pubmed/29507385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22449-9 |
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