Subdiaphragmatic Vagotomy With Pyloroplasty Ameliorates the Obesity Caused by Genetic Deletion of the Melanocortin 4 Receptor in the Mouse

Background/Objectives: We tested the hypothesis that abolishing vagal nerve activity will reverse the obesity phenotype of melanocortin 4 receptor knockout mice (Mc4r(−/−)). Subjects/Methods: In two separate studies, we examined the efficacy of bilateral subdiaphragmatic vagotomy (SDV) with pyloropl...

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Publicado en:Front Neurosci
Autores principales: Dezfuli, Ghazaul, Gillis, Richard A., Tatge, Jaclyn E., Duncan, Kimbell R., Dretchen, Kenneth L., Jackson, Patrick G., Verbalis, Joseph G., Sahibzada, Niaz
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838008/
https://ncbi.nlm.nih.gov/pubmed/29545738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00104
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