Deconvoluting Kinase Inhibitor Induced Cardiotoxicity

Many drugs designed to inhibit kinases have their clinical utility limited by cardiotoxicity-related label warnings or prescribing restrictions. While this liability is widely recognized, designing safer kinase inhibitors (KI) requires knowledge of the causative kinase(s). Efforts to unravel the kin...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Lamore, Sarah D., Ahlberg, Ernst, Boyer, Scott, Lamb, Michelle L., Hortigon-Vinagre, Maria P., Rodriguez, Victor, Smith, Godfrey L., Sagemark, Johanna, Carlsson, Lars, Bates, Stephanie M., Choy, Allison L., Stålring, Jonna, Scott, Clay W., Peters, Matthew F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Kinase Inhibitors and Cardiotoxicity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837613/
https://ncbi.nlm.nih.gov/pubmed/28453775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx082
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