ER-stress mobilization of death-associated protein kinase-1–dependent xenophagy counteracts mitochondria stress–induced epithelial barrier dysfunction

The gut microbiome contributes to inflammatory bowel disease (IBD), in which bacteria can be present within the epithelium. Epithelial barrier function is decreased in IBD, and dysfunctional epithelial mitochondria and endoplasmic reticulum (ER) stress have been individually associated with IBD. We...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Principais autores: Lopes, Fernando, Keita, Åsa V., Saxena, Alpana, Reyes, Jose Luis, Mancini, Nicole L., Al Rajabi, Ala, Wang, Arthur, Baggio, Cristiane H., Dicay, Michael, van Dalen, Rob, Ahn, Younghee, Carneiro, Matheus B. H., Peters, Nathan C., Rho, Jong M., MacNaughton, Wallace K., Girardin, Stephen E., Jijon, Humberto, Philpott, Dana J., Söderholm, Johan D., McKay, Derek M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836131/
https://ncbi.nlm.nih.gov/pubmed/29317503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000809
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