A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine

Ebola virus (EBOV) is a filamentous lipid-enveloped virus that causes hemorrhagic fever with a high fatality rate. Viral protein 40 (VP40) is the major EBOV matrix protein and regulates viral budding from the plasma membrane. VP40 is a transformer/morpheein that can structurally rearrange its native...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Del Vecchio, Kathryn, Frick, Cary T., Gc, Jeevan B., Oda, Shun-ichiro, Gerstman, Bernard S., Saphire, Erica Ollmann, Chapagain, Prem P., Stahelin, Robert V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836117/
https://ncbi.nlm.nih.gov/pubmed/29348171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.816280
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