The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK)

Protein trafficking can act as the primary regulatory mechanism for ion channels with high open probabilities, such as the renal outer medullary (ROMK) channel. ROMK, also known as Kir1.1 (KCNJ1), is the major route for potassium secretion into the pro-urine and plays an indispensable role in regula...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Mackie, Timothy D., Kim, Bo-Young, Subramanya, Arohan R., Bain, Daniel J., O'Donnell, Allyson F., Welling, Paul A., Brodsky, Jeffrey L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2018
Onderwerpen:
Protein Synthesis and Degradation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836112/
https://ncbi.nlm.nih.gov/pubmed/29311259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.819086
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