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A skeletal muscle L-type Ca(2+) channel with a mutation in the selectivity filter (Ca(V)1.1 E1014K) conducts K(+)
A glutamate-to-lysine substitution at position 1014 within the selectivity filter of the skeletal muscle L-type Ca(2+) channel (Ca(V)1.1) abolishes Ca(2+) flux through the channel pore. Mice engineered to exclusively express the mutant channel display accelerated muscle fatigue, changes in muscle co...
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| Published in: | J Biol Chem |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5836107/ https://ncbi.nlm.nih.gov/pubmed/29326166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.812446 |
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