A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop

Purpose: MicroRNA-630 plays dual roles in apoptosis and drug resistance in human cancers. However, the role of miR-630 in resistance to tyrosine kinase inhibitors (TKIs) in lung adenocarcinoma remains to be elucidated. Methods: Manipulation of miR-630 and its targeted gene YAP1 and/or combination of...

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Publicado en:Theranostics
Autores principales: Wu, De-Wei, Wang, Yao-Chen, Wang, Lee, Chen, Chih Yi, Lee, Huei
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835934/
https://ncbi.nlm.nih.gov/pubmed/29507618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.22048
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