Conserved Residues Lys(57) and Lys(401) of Protein Disulfide Isomerase Maintain an Active Site Conformation for Optimal Activity: Implications for Post-Translational Regulation

Despite its study since the 1960's, very little is known about the post-translational regulation of the multiple catalytic activities performed by protein disulfide isomerase (PDI), the primary protein folding catalyst of the cell. This work identifies a functional role for the highly conserved...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Caba, Cody, Ali Khan, Hyder, Auld, Janeen, Ushioda, Ryo, Araki, Kazutaka, Nagata, Kazuhiro, Mutus, Bulent
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835755/
https://ncbi.nlm.nih.gov/pubmed/29541639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2018.00018
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