Defining Bedaquiline Susceptibility, Resistance, Cross-Resistance and Associated Genetic Determinants: A Retrospective Cohort Study

BACKGROUND: Bedaquiline (BDQ) is a novel agent approved for use in combination treatment of multi-drug resistant tuberculosis (MDR-TB). We sought to determine BDQ epidemiological cut-off values (ECVs), define and assess interpretive criteria against putative resistance associated variants (RAVs), mi...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Ismail, Nazir A., Omar, Shaheed V., Joseph, Lavania, Govender, Netricia, Blows, Linsay, Ismail, Farzana, Koornhof, Hendrik, Dreyer, Andries W., Kaniga, Koné, Ndjeka, Norbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835552/
https://ncbi.nlm.nih.gov/pubmed/29337135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.01.005
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