Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene

Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role in the function and maturation of synapses and NLGN3 ASD-associated mutations disrupt hippocampal and cortical function. Here we show...

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Publicado no:Transl Psychiatry
Main Authors: Medina, Matías A., Andrade, Víctor M., Caracci, Mario O., Avila, Miguel E., Verdugo, Daniela A., Vargas, Macarena F., Ugarte, Giorgia D., Reyes, Ariel E., Opazo, Carlos, De Ferrari, Giancarlo V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835496/
https://ncbi.nlm.nih.gov/pubmed/29503438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-018-0093-y
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