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Activated PI3 Kinase Delta Syndrome: From Genetics to Therapy
Activated PI3 kinase delta syndrome (APDS) is a primary immunodeficiency caused by dominant mutations that increase activity of phosphoinositide-3-kinase δ (PI3Kδ). APDS can be caused by mutations in the PIK3CD gene that encodes PI3Kδ catalytic subunit p110δ (APDS1) or mutations in the PIK3R1 gene t...
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| Publicado no: | Front Immunol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5835040/ https://ncbi.nlm.nih.gov/pubmed/29535736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00369 |
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