CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis

OBJECTIVES: While various monocyte chemokine systems are increased in expression in osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating monocyte/macrophage recruitment to the OA joint remains poorly defined. Here, we investigated the relative contributions of the CC...

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Pubblicato in:Ann Rheum Dis
Autori principali: Raghu, Harini, Lepus, Christin M, Wang, Qian, Wong, Heidi H, Lingampalli, Nithya, Oliviero, Francesca, Punzi, Leonardo, Giori, Nicholas J, Goodman, Stuart B, Chu, Constance R, Sokolove, Jeremy B, Robinson, William H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834918/
https://ncbi.nlm.nih.gov/pubmed/27965260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2016-210426
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