Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals

Electron microscope studies have shown that the switched-off state of myosin II in muscle involves intramolecular interaction between the two heads of myosin and between one head and the tail. The interaction, seen in both myosin filaments and isolated molecules, inhibits activity by blocking actin-...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Lee, Kyoung Hwan, Sulbarán, Guidenn, Yang, Shixin, Mun, Ji Young, Alamo, Lorenzo, Pinto, Antonio, Sato, Osamu, Ikebe, Mitsuo, Liu, Xiong, Korn, Edward D., Sarsoza, Floyd, Bernstein, Sanford I., Padrón, Raúl, Craig, Roger
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834683/
https://ncbi.nlm.nih.gov/pubmed/29444861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715247115
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