Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals

Electron microscope studies have shown that the switched-off state of myosin II in muscle involves intramolecular interaction between the two heads of myosin and between one head and the tail. The interaction, seen in both myosin filaments and isolated molecules, inhibits activity by blocking actin-...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Lee, Kyoung Hwan, Sulbarán, Guidenn, Yang, Shixin, Mun, Ji Young, Alamo, Lorenzo, Pinto, Antonio, Sato, Osamu, Ikebe, Mitsuo, Liu, Xiong, Korn, Edward D., Sarsoza, Floyd, Bernstein, Sanford I., Padrón, Raúl, Craig, Roger
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834683/
https://ncbi.nlm.nih.gov/pubmed/29444861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715247115
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