Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway

Regulator of G protein signaling z1 (RGSz1), a member of the RGS family of proteins, is present in several networks expressing mu opioid receptors (MOPRs). By using genetic mouse models for global or brain region-targeted manipulations of RGSz1 expression, we demonstrated that the suppression of RGS...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Gaspari, Sevasti, Purushothaman, Immanuel, Cogliani, Valeria, Sakloth, Farhana, Neve, Rachael L., Howland, David, Ring, Robert H., Ross, Elliott M., Shen, Li, Zachariou, Venetia
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834666/
https://ncbi.nlm.nih.gov/pubmed/29440403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707887115
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