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Interacting Amino Acid Replacements Allow Poison Frogs to Evolve Epibatidine Resistance
Animals that wield toxins face self-intoxication. Poison frogs have a diverse arsenal of defensive alkaloids that target the nervous system. Among them is epibatidine, a nicotinic acetylcholine receptor (nAChR) agonist that is lethal at microgram doses. Epibatidine shares a highly conserved binding...
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| Veröffentlicht in: | Science |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5834227/ https://ncbi.nlm.nih.gov/pubmed/28935799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan5061 |
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