Interacting Amino Acid Replacements Allow Poison Frogs to Evolve Epibatidine Resistance

Animals that wield toxins face self-intoxication. Poison frogs have a diverse arsenal of defensive alkaloids that target the nervous system. Among them is epibatidine, a nicotinic acetylcholine receptor (nAChR) agonist that is lethal at microgram doses. Epibatidine shares a highly conserved binding...

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Gepubliceerd in:Science
Hoofdauteurs: Tarvin, Rebecca D., Borghese, Cecilia M., Sachs, Wiebke, Santos, Juan C., Lu, Ying, O’Connell, Lauren A., Cannatella, David C., Harris, R. Adron, Zakon, Harold H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834227/
https://ncbi.nlm.nih.gov/pubmed/28935799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan5061
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