Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer

BACKGROUND: Based upon preclinical synergy in murine models, we carried out a phase I trial to determine the maximum tolerated dose (MTD), toxicities, pharmacokinetics, and biomarkers of response for the combination of BKM120, a PI3K inhibitor, and olaparib, a PARP inhibitor. PATIENTS AND METHODS: O...

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Enregistré dans:
Détails bibliographiques
Publié dans:Ann Oncol
Auteurs principaux: Matulonis, U. A., Wulf, G. M., Barry, W. T., Birrer, M., Westin, S. N., Farooq, S., Bell-McGuinn, K. M., Obermayer, E., Whalen, C., Spagnoletti, T., Luo, W., Liu, H., Hok, R. C., Aghajanian, C., Solit, D. B., Mills, G. B., Taylor, B. S., Won, H., Berger, M. F., Palakurthi, S., Liu, J., Cantley, L. C., Winer, E.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834157/
https://ncbi.nlm.nih.gov/pubmed/27993796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdw672
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