Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis

BACKGROUND: Distant metastasis accounts for 90% of deaths from colorectal cancer (CRC). Genomic heterogeneity has been reported in various solid malignancies, but remains largely under-explored in metastatic CRC tumors, especially in primary to metastatic tumor evolution. PATIENTS AND METHODS: We co...

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Detalhes bibliográficos
Publicado no:Ann Oncol
Main Authors: Wei, Q., Ye, Z., Zhong, X., Li, L., Wang, C., Myers, R. E., Palazzo, J. P., Fortuna, D., Yan, A., Waldman, S. A., Chen, X., Posey, J. A., Basu-Mallick, A., Jiang, B. H., Hou, L., Shu, J., Sun, Y., Xing, J., Li, B., Yang, H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834069/
https://ncbi.nlm.nih.gov/pubmed/28911083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdx278
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