Dual MET and ERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC)

BACKGROUND: Third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as osimertinib are the last line of targeted treatment of metastatic non-small-cell lung cancer (NSCLC) EGFR-mutant harboring T790M. Different mechanisms of acquired resistance to third-generati...

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Detalhes bibliográficos
Publicado no:Ann Oncol
Main Authors: Martinez-Marti, A, Felip, E, Matito, J, Mereu, E, Navarro, A, Cedrés, S, Pardo, N, Martinez de Castro, A, Remon, J, Miquel, J M, Guillaumet-Adkins, A, Nadal, E, Rodriguez-Esteban, G, Arqués, O, Fasani, R, Nuciforo, P, Heyn, H, Villanueva, A, Palmer, H G, Vivancos, A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834054/
https://ncbi.nlm.nih.gov/pubmed/28961841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdx396
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